Runeterra Relics
Kai'Sa banner
Shurima region icon
Excellent (8/10)

Kai'Sa is widely considered one of the strongest champions in the Shurima region, particularly at maximum investment. While her early game can be slow at lower star levels, her unique 5-star and 6-star upgrades transform her into a highly efficient, fast-paced threat capable of consistent early-turn victories.

Optimal C6 Keyword Distribution
  • Perfect Hex Core icon

    Provides additional keywords per round. If you don't have her 'Star of Legends' that grants support champions 'Scout', you want to use 'Galeforce' here.

  • Full Build icon

    Grants Challenger, Tough, and Overwhelm

  • Queen's Embrace icon

    Grants Spirit, Impact, and Evolve. This acts as a direct upgrade to Dreams of Yordles

Strategy

This build is strictly optimized for Kai'Sa at 6 stars. At this level, her Second Skin spell applies all of her keywords to an allied target.

You want to be building around the best support champion you can play on Turn 1, stack all items on them, and ignore that Kai'sa exists. Play the support champ, play Second Skin, and go to town.

Pre-C6 Skill Damage Amplifier
  • Luden's Tempest icon

    Increases the damage of all spells and skills by 1. This doubles the damage of levelled up Kaisa's Icathian Rain skill.

  • Luden's Tempest icon

    Stacks with the first Luden's Tempest to further amplify skill damage.

  • Full Build icon

    Grants Kaisa additional keywords to assist in her evolution.

Strategy

This build is highly effective for accounts that have not yet reached 6 stars. It focuses entirely on maximizing the damage of Kai'Sa's Icathian Rain skill.

By equipping two copies of Luden's Tempest, each missile deals significantly more damage, allowing her to clear the enemy board and inflict heavy Nexus damage immediately upon leveling up.

Other Relic Options
  • Perfect Hex Core icon

    An excellent choice prior to 6 stars. It consistently generates new keywords every round, accelerating her Evolve condition and scaling her skill damage.

  • Black Shield icon

    A potent defensive option that grants SpellShield and contributes an additional keyword to her Evolve requirement.

  • Chosen by the Stars icon

    Highly effective before 6 stars for its Fated and Augment synergy. However, its granted keywords (Overwhelm, Regeneration, Challenger) do not transfer via her 6-star Second Skin ability unless she is already on the board and empowered.

Constellation
  • Icon for From Prey to Predator

    From Prey to Predator

    Round Start: If you have the attack token, grant your strongest ally a random positive keyword.
  • Icon for Voidtouched

    Voidtouched

    +1 Starting Mana. Allies with 3+ positive keywords have +2|+2.
  • Icon for From Prey to Predator II

    From Prey to Predator II

    Round Start: Grant your strongest ally a random positive keyword.
  • Icon for Dragon's Rage

    Dragon's Rage

    When you summon an ally, grant it FuryFury. It is a Dragon.
    Review

    Players disagree about the necessity of her 4-star power. Some consider it a helpful boost for consistent level-ups and early board presence, while others find it less impactful than her other constellation upgrades.

  • Icon for Voidtouched II

    Voidtouched II

    +2 Starting Mana. Allies with 3+ positive keywords have +2|+2, and allies with 6+ positive keywords have +4|+4.
    Review

    This upgrade replaces her 2-star power, granting +2 starting mana and an enhanced stat buff for units with keywords. This is considered a massive power spike that resolves her slow early game and provides essential scaling for difficult encounters.

  • Icon for Wield The abyss

    Wield The abyss

    Round Start: Create a Second Skin in hand. When you target an ally with Second Skin, give it Kai'Sa's keywords this round.
    Review

    Grants a fleeting Second Skin every round that shares Kai'Sa's keywords with the target. This fundamentally changes her playstyle, allowing her to turn any low-cost unit into a massive threat with keywords like Scout and Overwhelm, often securing victories as early as turn 1.

Gameplay Tips
  • Prioritize Unique Keywords

Drafting units and powers that provide unique keywords is essential. Kai'Sa requires 6 unique keywords to Evolve, and every additional keyword increases the damage of her Icathian Rain skill.

  • The Value of Double Attack

Acquiring the Double Attack keyword during an adventure is the single most powerful upgrade Kai'Sa can receive. It drastically multiplies her damage output and should be prioritized above all other item drafts.

  • Leverage Support Champions at 6 Stars

Once Kai'Sa reaches 6 stars, her optimal strategy involves playing a low-cost support champion and buffing them with Second Skin. This allows you to push massive damage with Scout and Overwhelm before Kai'Sa even needs to enter combat.

  • Beware of Cost-Increasing Mutators

Adventures or mutators that increase the cost of created cards severely hinder Kai'Sa's performance. Her Second Skin spell is a created card, and increasing its cost disrupts her primary scaling mechanic.

  • Chosen by the Stars Interaction (C6)

If using Chosen by the Stars at 6 stars, be aware that its empowered keywords (Overwhelm, Regeneration, Challenger) will not transfer to allies via Second Skin unless Kai'Sa has 10+ power while in your hand. This requires external hand-buffs to function properly.