
Vayne
View on WikiExcellent (8/10)
High Investment Required
Epic Relics
Players disagree about Vayne's gameplay loop. Some consider her rapid, multi-attack playstyle highly engaging and efficient for clearing content. While others find her linear, repetitive, and overly reliant on drawing her champion card.
Optimal Aggression
Provides essential keywords like Challenger and Overwhelm, alongside significant stat scaling, preventing enemies from effectively blocking her damage.
Ensures she survives multiple attacks against large enemy units, which is critical for her aggressive game plan.
Provides the immediate spell mana required to cast Tumble on the turn she is played, maximizing Turn 1 lethality.
Strategy
This combination maximizes Vayne's early-game lethality. Hidden Tome provides the spell mana needed to immediately cast Tumble, allowing her to attack multiple times on the turn she is deployed. Death's Foil guarantees her survival during these repeated strikes, while Chosen by the Stars ensures her damage pierces through blockers and scales rapidly.
Scaling Combatant
Grants critical offensive keywords and continuous stat growth.
Provides a substantial stat boost to consistently activate the Empowered effect of Chosen by the Stars.
Maintains board presence by preventing damage during her frequent attacks.
Strategy
For accounts that have not yet unlocked her maximum constellation upgrades, Fear-Cleaving Axe provides the necessary raw stats to quickly activate the Empowered threshold of Chosen by the Stars. This build focuses on overwhelming the opponent with high combat stats, utilizing Death's Foil to safely execute multiple attacks per round.
Accessible Aggression
Provides necessary stat scaling to threaten the enemy Nexus.
Grants Challenger to the entire board, allowing Vayne to dictate favorable trades.
Serves as a budget alternative to Hidden Tome, ensuring Vayne has the spell mana required to cast Tumble immediately.
Strategy
This build utilizes only Rare and Common relics to establish early dominance. The Bounty Hunter's Renown scales her stats, while Laurent Bladerack allows her to pull key threats out of the way or force favorable trades. Lost Chapter guarantees the spell mana needed to initiate her Tumble sequence as soon as she hits the board.
Other Relic Options
Doubles Vayne's stats, providing a massive offensive spike, though it requires additional spell mana to cast early.
Grants immediate access to Overwhelm and Challenger, serving as a viable alternative to Chosen by the Stars for immediate Turn 1 pressure.
This relic is ineffective on Vayne. Because her core mechanic involves constantly swapping equipped weapons, the stat buffs provided by Living Weapon are repeatedly lost, making it a suboptimal choice.
While it offers stat scaling, Vayne's strategy relies on a single, powerful unit rather than developing a wide board of allies to consume, making this relic inconsistent.
Vayne's optimal performance is heavily restricted to a few specific Epic relics. Deviating from her core setup often results in a significant drop in consistency, especially in high-difficulty encounters.
Constellation
Vayne requires significant constellation investment to reach her full potential. Her early star powers offer minimal impact, making her highly dependent on reaching her later upgrades to function effectively in challenging adventures.

It must do something...
Round Start: If you have the attack token and fewer than 2 equipment in hand, create a Golden Spatula.
Night Hunter
+1 Starting Mana. When an ally is equipped, give it Scout this round.
It must do something... II
Round Start: If you have the attack token and fewer than 2 equipment in hand, create a Golden Spatula. Grant it a random keyword.Review
This upgrade provides minimal impact on her overall game plan and does not significantly alter her early-game consistency.
Armed To The Teeth
Allies with Equipment or attachments have +2|+2.Review
Provides a necessary baseline stat increase, improving her survivability and damage output before she can scale through relics.
Manaflow
Game Start: Get a mana gem.Review
This is a critical upgrade. The cost reduction on Tumble is essential for enabling her to be played and attack multiple times on Turn 1, drastically accelerating her win condition.
Purge With Silver
When an ally attacks, give it +4|+0 this round.Review
Transforms Vayne into a highly lethal threat capable of ending games on the first or second turn. The massive attack bonuses granted per strike synergize perfectly with her multi-attack playstyle, though it requires her to be safely established on the board.
Gameplay Tips
- Mulligan Aggressively for Vayne
Because her entire strategy revolves around her multi-attack capabilities, failing to draw Vayne early often results in a loss. Prioritize finding her in the opening hand above all other cards.
- Maximize Turn One Pressure
The optimal sequence involves playing Vayne, declaring an attack, casting Tumble to rally and equip, and attacking again. This sequence applies immense early pressure that the AI struggles to counter.
- Bait Enemy Removal
Vayne is highly vulnerable to hard removal, Stun, and Frostbite effects. When facing opponents with strong control tools, wait until the AI has depleted its mana before deploying her to the board.
- Ignore Board Development
Vayne's game plan is entirely focused on a single, powerful unit. Do not waste resources developing a wide board of followers; instead, focus all mana and items on protecting and buffing Vayne.
- Navigate Cost-Increasing Modifiers
Adventures that increase the cost of created cards will delay Vayne's Tumble. While this slows down her Turn 1 lethality, her inherent scaling allows her to recover and secure victories on subsequent turns.