Vayne
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Excellent (8/10)
High Investment Required
Epic Relics
Players disagree about Vayne's gameplay loop. Some consider her rapid, multi-attack playstyle highly engaging and efficient for clearing content. While others find her linear, repetitive, and overly reliant on drawing her champion card.
Optimal Aggression
Zoe Specialized
Provides essential keywords like Challenger and Overwhelm, alongside significant stat scaling, preventing enemies from effectively blocking her damage.
Ensures she survives multiple attacks against large enemy units, which is critical for her aggressive game plan.
Provides the immediate spell mana required to cast Tumble on the turn she is played, maximizing Turn 1 lethality.
Strategy
This combination maximizes Vayne's early-game lethality and is widely considered her definitive setup for 6-star play. Hidden Tome provides the spell mana needed to immediately cast Tumble, allowing her to attack multiple times on the turn she is deployed.
Death's Foil guarantees her survival during these repeated strikes against large enemy units, which is critical for her aggressive game plan. Chosen by the Stars ensures her damage pierces through blockers with Overwhelm and scales rapidly with Fated and Augment.
Pre-C6 Scaling Combatant
- Grants critical offensive keywords and continuous stat growth.
- Maintains board presence by preventing damage during her frequent attacks.
Provides a substantial stat boost to consistently activate the Empowered effect of Chosen by the Stars.
Strategy
For accounts that have not yet unlocked her maximum constellation upgrades, Fear-Cleaving Axe provides the necessary raw stats to quickly activate the Empowered threshold of Chosen by the Stars.
This build focuses on overwhelming the opponent with high combat stats, utilizing Death's Foil to safely execute multiple attacks per round. Once Vayne reaches 6 stars and gains inherent attack scaling, Fear-Cleaving Axe is typically replaced by Hidden Tome.
Accessible Aggression
Capitalizes on Vayne's multiple attacks per round to rapidly scale her offensive stats.
Grants Challenger to the entire board, allowing Vayne to dictate favorable trades and pull blockers away.
Serves as a budget alternative to Hidden Tome, ensuring Vayne has the spell mana required to cast Tumble immediately upon being played.
Strategy
This build utilizes only Rare and Common relics to establish early dominance. Guinsoo's Rageblade synergizes perfectly with her multi-attack loop, rapidly scaling her offensive stats.
Laurent Bladerack allows her to pull key threats out of the way, ensuring safe attacks. Lost Chapter guarantees the spell mana needed to initiate her Tumble sequence as soon as she hits the board.
Other Relic Options
Synergizes strongly with Vayne's mechanics, allowing her to consume weak allies to consolidate stats and keywords onto herself, ensuring she remains the primary lethal threat.
Doubles Vayne's stats, providing a massive offensive spike, though it requires additional spell mana to cast early.
Grants immediate access to Overwhelm and Challenger, serving as a viable alternative to Chosen by the Stars for immediate Turn 1 pressure.
This relic is highly ineffective on Vayne. Because her core mechanic involves constantly swapping equipped weapons via Tumble, the stat buffs provided by Living Weapon are repeatedly lost, making it a suboptimal choice.
This relic is too slow for Vayne's aggressive game plan. It refills spell mana at the start of the next round, whereas Vayne requires immediate spell mana on the turn she is played to cast Tumble.
Vayne's optimal performance is heavily restricted to a few specific Epic relics. Deviating from her core setup often results in a significant drop in consistency, especially in high-difficulty encounters.
Constellation
Vayne requires significant constellation investment to reach her full potential. Her early star powers offer minimal impact, making her highly dependent on reaching her later upgrades to function effectively in challenging adventures.
It must do something...
Round Start: If you have the attack token and fewer than 2 equipment in hand, create a Golden Spatula.
Night Hunter
+1 Starting Mana. When an ally is equipped, give it Scout this round.
It must do something... II
Round Start: If you have the attack token and fewer than 2 equipment in hand, create a Golden Spatula. Grant it a random keyword.
Armed To The Teeth
Allies with Equipment or attachments have +2|+2.Review
Provides a crucial stat boost that significantly improves Vayne's survivability and offensive scaling, making her early game much more comfortable.
Manaflow
Game Start: Get a mana gem.Review
Essential for her aggressive game plan. The mana acceleration or cost reduction allows Vayne to be deployed and cast Tumble on Turn 1, which is critical for high-difficulty encounters.
Purge With Silver
When an ally attacks, give it +4|+0 this round.Review
Transforms Vayne into a First Turn Kill powerhouse. The massive attack scaling ensures she can stat-check almost any encounter, solidifying her as a top-tier speedrunner.
Gameplay Tips
- Mulligan Aggressively for Vayne
Because her entire strategy revolves around her multi-attack capabilities, failing to draw Vayne early often results in a loss. Prioritize finding her in the opening hand above all other cards.
- Maximize Turn One Pressure
The optimal sequence involves playing Vayne, declaring an attack, casting Tumble to rally and equip, and attacking again. This sequence applies immense early pressure that the AI struggles to counter.
- Bait Enemy Removal
Vayne is highly vulnerable to hard removal, Stun, and Frostbite effects. When facing opponents with strong control tools, wait until the AI has depleted its mana before deploying her to the board.
- Ignore Board Development
Vayne's game plan is entirely focused on a single, powerful unit. Do not waste resources developing a wide board of followers; instead, focus all mana and items on protecting and buffing Vayne.
- Navigate Cost-Increasing Modifiers
Adventures that increase the cost of created cards will delay Vayne's Tumble. While this slows down her Turn 1 lethality, her inherent scaling allows her to recover and secure victories on subsequent turns.
- Zoe Adventure Strategy
In the 10-star Zoe adventure, Vayne must be wary of burst-speed Polymorph effects and the damage-halving landmark. Prioritize acquiring SpellShield during the run to protect her from immediate removal.